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Larger organisms with increased cell counts have a theoretically increased risk of cancer; the observation that larger species do not seem to have an increased cancer risk in contradiction to the patterns observed between members within species is known as Peto’s Paradox. ere, we show that elephants and their extinct relatives (proboscideans) may have resolved Peto’s paradox in part through refunctionalizing a leukemia inhibitory factor pseudogene (LIF6) with pro-apoptotic functions. LIF6 is transcriptionally upregulated by TP53 in response to DNA damage and translocates to the mitochondria where it induces apoptosis.
Cell Rep, 2018

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Last updated: 2018-10-12 workflowr checks: (Click a bullet for more information) ✖ R Markdown file: uncommitted changes The R Markdown is untracked by Git. To know which version of the R Markdown file created these results, you’ll want to first commit it to the Git repo. If you’re still working on the analysis, you can ignore this warning. When you’re finished, you can run wflow_publish to commit the R Markdown file and build the HTML.

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Introduction There are always some big papers which one cites left and right, because they’ve generated a very important dataset, or have a very succinct paper. Here, I will be using R to improve upon these original graphs, and also provide an interactive view of them. Libraries library(tidyverse) options(readr.num_columns = 0) library(ggrepel) library(ggpubr) library(plotly) SEER Cancer Statistics: Cancer Incidence as a Function of Age seer <- read_lines( ".

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Introduction While aging is an inevitable process for most species, there is an incredible diversity of lifespans throughout the Tree of Life, ranging from a few days to several millenia. For researchers interested in the fundamental biology behind aging, seeing what aspects of an organism’s biology correlate to lifespan is an important first step on the path to finding concrete explanations behind their longevity.

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Gene Duplications in Peto's Paradox

Are cases of individual tumor suppressor duplications in Peto’s Paradox lineages one-off events, or part of a general mechanism?